Part 3 of 4 (Series on oncology)

Calcium ion (Ca2+) is a ubiquitous and versatile signaling molecule that regulates a wide array of cellular processes, including proliferation, cell death, migration, and immune response, which are crucial for cancer development. In recent decades, the disruption of Ca2+ homeostasis has been recognized as a critical factor in the initiation and progression of malignant diseases. Notably, Ca2+ also plays a pivotal role in modulating proto-oncogenes and tumor suppressor genes through intracellular signaling pathways.

Introduction

Active ionic calcium plays a pivotal role in cancer therapy by influencing critical processes such as tumor growth, cell survival, and the alkalization of the tumor microenvironment. By restoring calcium signaling, AIC Therapy regulates proto-oncogenes and tumor suppressor genes, modulates intracellular signaling pathways, activates mitochondrial function, and prevents p53 mutations, offering a systemic approach to cancer treatment.

Calcium's Role in Regulating Cancer Through Proto-Oncogenes and Tumor Suppressor Genes

Calcium plays a crucial role in regulating proto-oncogenes and tumor suppressor genes by modulating intracellular signaling pathways, which can either promote or inhibit cancer cell proliferation, depending on the cellular context. Specifically, calcium influences the expression and activity of proto-oncogenes like c-Myc through calcium-dependent pathways that reduce cancer cell growth. Additionally, calcium activates tumor suppressor genes, such as p53, through pathways that trigger apoptosis and inhibit tumor progression. Maintaining the balance of intracellular calcium levels is essential for preserving the activity of tumor suppressor genes, helping to prevent uncontrolled cell proliferation in cancer. AIC Therapy offers a therapeutic strategy for inhibiting cancer growth and progression by influencing both proto-oncogenes and tumor suppressor genes.

Figure 2 shows that tumor suppressor genes play a crucial role in regulating calcium homeostasis within cancer cells, influencing both calcium storage in the endoplasmic reticulum (ER) and its release into the cytosol and mitochondria. Calcium affects tumor suppressors like p53, which enhances SERCA pump activity at the ER, thereby increasing calcium signaling. PTEN, another tumor suppressor, interacts with IP3R to protect it from AKT-mediated phosphorylation, ensuring proper calcium release from the ER. Proteins like PML and BAP1 stabilize calcium channels, maintaining their function and promoting apoptosis, while Bok supports the connection between the ER and mitochondria, facilitating calcium transfer and inducing cell death. These mechanisms illustrate how calcium and tumor suppressors collaborate to counteract cancer cell survival.

https://pubmed.ncbi.nlm.nih.gov/35915027/

Clinical Case 1

A 59-year-old male with Stage 4 pancreatic cancer demonstrated optimal condition by February 2012 after initiating AIC Therapy in 2011, following his second round of chemotherapy. A 48-year-old female with Stage 3 pancreatic cancer commenced AIC Therapy in August 2013 and subsequently achieved full recovery, with a regimen of 2-3 doses per day. Another case involves a 42-year-old female who experienced a 2-degree increase in body temperature following 10 days of AIC Therapy after undergoing surgery. Additionally, a 61-year-old female with pancreatic cancer showed no evidence of metastasis or abnormal hypermetabolic lesions after one year of AIC Therapy, as verified by her oncologist in November 2016. These clinical cases suggest that AIC Therapy can play a significant role in improving or stabilizing the conditions of pancreatic cancer patients at various stages of the disease.

Clinical Case 2

A 58-year-old male with stage 4 colorectal cancer, initially deemed inoperable, showed remarkable clinical improvement after 45 days of AIC Therapy. The patient successfully excreted a significant portion of the tumor mass, allowing for a subsequent surgical procedure to address scarring. The patient maintained good overall health throughout this period, including a strong appetite, indicating the therapy's efficacy. The patient's regimen also included periods of water fasting, which may have enhanced the therapeutic effects. This case demonstrates the effectiveness of AIC Therapy in inducing tumor regression and improving the condition of patients with advanced cancer.

Figure 3 Tumor Excretion in Advanced Colorectal Cancer Following AIC Therapy.

Conclusion:

AIC therapy works by boosting the activity of important genes that help stop cancer, like p53, while also lowering the activity of genes that can promote cancer, such as c-Myc.  AIC Therapy modulates proto-oncogenes and tumor suppressor genes, inhibiting tumor growth and progression.

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Join our community today and get instant access to cutting-edge research on AIC Therapy for your patient’s treatments. Thank you for reading.

Server Bozdogan MD, PhD.

ACRI Research Director

Read about More Benefits of AIC Therapy

Fibromyalgia case

Not too long ago, I started to feel pain around my body and could not sleep soundly. I thought it was caused by running after my rowdy kids. However, instead of symptoms going away with rest, it was getting worse, keeping me from getting good sleep due to felt pain all around my body. When massage sessions and acupuncture did not help, I visited my family doctor last summer. Revising the clinic after the initial blood test, he prescribed pain relievers and muscle relaxants, which did not alleviate the painful condition much. I became cranky and naggy and made everyone in my family miserable.

My family doctor recommended me to a specialist who prescribed me a new medication, saying that an abnormality in the muscle fibers caused the pain. (Fibromyalgia) The medication helped a bit, and I was relieved as I could sleep better. However, maybe a week had passed, and my back started to hurt again, soon spreading to my whole body. The pain disrupted every part of my life, and I began to think whether living like this had any meaning.

Then, one day I heard about miraculous healing stories of AIC Therapy and, in desperation, decided to try it out. I don't know how much I slept after taking AIC. I have never slept so deeply for a long time. It helped alleviate the pain, and I am writing this to thank you for the excellent therapy. Now freed from pain, every day is a gift. Thank you~

(Mary Kim, female, 43, Vancouver, Canada)

PPS(Post Polio Syndrome) almost pulled my life down, but with MaraGen, I am walking strong again!

I spent a sickly childhood after suffering from polio. I thought polio was a once-in-a-lifetime thing that would never haunt me again. However, I could not believe the nightmare was back when I was diagnosed with Post Polio Syndrome (PPS). My legs began to lose leg strength to the point I dreaded going to the bathroom. Thoughts of stopping the work I enjoyed were devastating. I questioned if there was any hope left. However, my sister-in-law (pharmacist) recommended that I try MaraGen in Korea last spring (2016). I was not fully convinced but decided to take it anyway. By summer I had enough strength in my legs to take a trip to South America. Now, I can go to the bathroom easily and am still working! I am so thankful!

(Rebecca L. – Age 66, Female, Surrey, BC, Canada)

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