AICTHERAPY IN A NUTSHELL
Studies on degenerative conditions indicate that more than 150 chronic ailments are linked to disturbances in cellular calcium equilibrium. Hormonal changes associated with aging and chronic bone loss can deplete vital cellular calcium reservoirs, disrupting calcium signaling and triggering mitochondrial dysfunction and oxidative stress.
To counteract the damaging effects of calcium dysfunction, Antiorbital Ionic Calcium (AIC) therapy uses a formula that releases ionic calcium, initiating a healing cascade of hormones. AIC stimulates physiological responses that are sensitive to ionic calcium and combats illnesses at their core.
The Discovery That Made a Difference
Anti-orbital Ionic Calcium Carbonate (AIC-CaCO3)
How is AIC Calcium Carbonate Different?
Introducing AIC - the first calcium-ion-delivering calcium carbonate in the world. It safely and effectively increases the concentration of calcium ions in our blood. Through the utilization of a weak anti-orbital chemical bonding to calcium carbonate molecules and stabilizing it inside structured water molecules, AIC calcium carbonate displays unique physical and chemical properties. It is 200 times more soluble and 3 times more active chemically.
Molecules exhibit electrical polarity due to anti-orbital bonding, which attracts water molecules through hydrogen bonding. Achieving stability of antibonding at room temperature was a significant technological breakthrough that took ten years of research and development.
How Does AIC Calcium Carbonate Work?
The weak chemical bonding of AIC allows calcium ions to detach easily and be passively absorbed through the stomach lining via diffusion and osmotic pressure. Unlike other calcium products, this process does not require digestion, vitamin D, or peptides.
Because the body is highly sensitive to changes in serum ionic calcium levels, even a small increase from AIC may trigger hormonal responses such as TSH and calcitonin release, activating bone-building osteoblasts. AIC therapy uses ionic calcium as a signaling agent to stimulate the body’s self-healing responses, helping reverse calcification at the cellular and systemic levels and supporting overall health. Its unique healing pathway distinguishes AIC from other treatments.
During regular calcium digestion, both positively charged calcium ions and negatively charged anions are produced, resulting in an electrically neutral outcome. However, in the case of AIC, it dissolves on the stomach wall into calcium ions and neutral molecules like oxygen and carbon dioxide without any negative charges, resulting in a net positive charge.
Whether from food or supplements, when calcium is digested in our stomach by strong hydrochloric acid, calcium ions are released as the ionic bond of the molecules is broken, and both cations and anions are released. However, the net charge of the reaction is zero. All calcium ions descend to the small intestine, where it binds with vitamin D and peptides and are absorbed as protein-bound calcium.
What is antiorbital calcium?
AIC is the world's first safe calcium-ion delivering molecule administered orally. Ionic calcium triggers body-wide calcium homeostasis no other calcium supplementation can achieve.
What is Antiorbital Bonding?
Anti-bonding orbitals are essentially the “opposite” of bonding orbitals.
AIC calcium’s anti-orbital bonding keeps the calcium atoms in the molecule very loose and unstable.
Our innovative technology locks calcium atoms in place until they are released into our body. A highly advanced process formulates it to maintain positive charges (2+) by altering the bonding structure into anti-bonding. The positive charges of the molecule attract water molecules to cluster around it, making it incredibly water-soluble and allowing direct and passive absorption into the body.
AIC calcium absorption is passive without the energy required
Calcium from AIC is rapidly absorbed due to its positively charged anti-orbital bonding, allowing it to remain in an ionized form that is readily available for the body to use. This enables calcium to participate more directly in essential physiological functions such as cellular signaling, muscle activity, and bone metabolism.
In contrast, conventional calcium sources require digestion with stomach acid, peptides, and vitamin D to be absorbed through active transport in the small intestine. This multi-step process can become less efficient with age or metabolic imbalance, potentially limiting how much calcium is effectively utilized. AIC is described as bypassing these steps, offering more immediate bioavailability, and potentially supporting more efficient calcium utilization in the body.
AIC Calcium Ions Stay in Active Form
AIC is absorbed only as ionic calcium and is wrapped in a coordination bond of water molecules, avoiding binding with albumin, increasing ionic calcium in the blood, and affecting hormones, enzymes related to calcium channels, various cell metabolism activities, and p53 function activation, etc.
Calcium absorbed by vitamin D directly combines with albumin and becomes protein calcium. When AIC calcium is absorbed, it forms a coordination bond with water molecules and, even in the blood, does not combine with albumin, so it acts as ionic calcium and can enter calcium channels of the cell.
There is about 200g of albumin in the blood, and calcium that is actively transported is immediately bound because albumin contains amino acids with anions. Of course, it also becomes ionic calcium, but it does not deviate from calcium homeostasis and does not affect the human body. Rather, it may contribute to calcification.
Active Transport of Regular Calcium
Regular calcium intake from diet or supplements requires strong stomach acid, along with peptides and vitamin D3, to be properly digested and absorbed in the small intestines as protein-bound calcium. This process is not readily utilized with aging due to factors such as a sedentary lifestyle, hormonal changes, and poor diet.
As a result, various side effects of inactive or poorly utilized calcium may occur, including kidney stones, blood vessel calcification, stroke, and heart attack, among others. Most, if not all, calcium supplements fall into this category and may aggravate body-wide calcification over time. This accumulation of calcium in inappropriate tissues is considered by many to be one of the major contributing factors in the development and progression of degenerative diseases.
Passive Transport of AIC Calcium
Unlike regular calcium intake, no Vitamin D3 or peptides are needed for absorption. AIC diffuses passively through digestive tract cell linings (mucosa) as ions, not requiring physiological energy from our body, and is readily available for immediate use.
Ionic calcium is immediately utilized to bring calcium homeostasis :
* Corrects calcium signaling
* Reduces cellular oxidative stress
* Restores mitochondrial function
* Triggers decalcification
AIC is Absorbed Through the Entire Digestive Tract
If secretions from the bile duct and pancreas are normal, absorption occurs mainly in the duodenum. For administration, a 500 cc diluted solution should be divided into 100–150 cc portions and consumed separately. In this method, most AIC is absorbed in the duodenum, with 5% or less absorbed in the small intestine.
This method is recommended for patients who have undergone partial or total gastrectomy due to stomach cancer, since nutrients not absorbed through the gastric mucosa can still be absorbed in the duodenum. One calcium atom in AIC, coordinated with six water molecules, is absorbed without vitamin D and enters the bloodstream without binding to albumin, remaining in its ionic form. This process occurs in the stomach and duodenum.
In contrast, regular calcium requires vitamin D for absorption and quickly binds to albumin in the bloodstream, existing as protein-bound calcium.
AIC is Absorbed through Diffusion & Osmotic Pressure
About 5 to 8 mg of AIC solution is mixed with 500ml of water for optimum absorption as ionic calcium. AIC is taken on an empty stomach and is completely absorbed within 30 minutes through diffusion and osmotic pressure.
Although it is in a small intake amount, a slight elevation of serum ionic calcium level is enough to trigger TSH (thyroid-stimulating hormone) to initiate strong bone-building osteoblasts. AIC’s cascading effects on the physiological functions of our body also activate inactive protein-bound calcium in our blood to boost further and maintain good bone health.
Channel & Intracellular Calcium ion Levels
Modes of regulated calcium entry across the membrane
AIC is the first calcium-ion-delivery-system to help build and support strong bones while promoting normal bone mass. AIC also plays an important role in other functions such as nerve transmission and muscular function. Unlike other electrically neutral calcium supplements that require Active Transport, AIC calcium’s Passive Transport brings full absorption of calcium without the need for Vitamin D, peptide, or other agents.
Inside our cells, AIC ionic calcium quickly breaks down to yield calcium ions, which are absorbed into capillaries and triggers our body’s natural bone formation process.
STRONGER BONES LEAD TO A HEALTHIER LIFE
According to a follow-up study conducted in Denmark with 35,000 participants, individuals in their 50s with strong bones had a life expectancy that was 11.6 years longer than those with weaker bones.
Recent research also shows that senior women who have low bone density are more than twice likely to develop Alzheimer's disease.
Physiological Effects of ionic calcium therapy
After intake, AIC’s effect lasts about four hours in our body, initially raising the serum ionic calcium concentration to a higher yet safe level to trigger various physiological functions before bringing down the serum ionic calcium concentration down to the average physiological level.
While ionic calcium level is elevated, bone-building osteoblast with osteoclastic activity is triggered to raise the bone turnover rate, repairing and rebuilding bones. This process also activates idle protein-bound calcium, releasing both ionic calcium and protein, further fueling bone-building and clearing body-wide calcification. Ionic calcium also aids cellular metabolism, releasing more ATP (adenosine triphosphate) and raising body temperature. As kidneys try to excrete excess ionic calcium through urination, an urge to urinate within an hour of taking AIC is experienced, which is both healthy and normal, indicating that AIC is working.
Bone Loss Leads to 150+ Degenerative Diseases
Bone health is directly related to our overall health. Emptier bone characterized by osteoporosis or osteopenia indicates a higher risk of fracture and a greater chance of developing degenerative diseases. Why? Because emptying bones cause calcification in both cellular and systemic levels, causing cellular communications mayhem by disrupting calcium signaling.
Bone density peaks around age 30 and starts to decrease around age 35. Women with menopause have a sharper decline than men, posing a higher risk of osteoporosis. Stress, a sedentary lifestyle, and toxins accelerate the drop.
Cellular Calcification can lead to Mitochondrial Dysfunction, Cellular Inflammation, Oxidative Stress, and Calcium Signaling Breakdown.
CATEGORY A
Most people fall under this category. With aging, parathyroid hormone (PTH) becomes more active and takes out more calcium ions from bones than needed, causing weaker bones and body-wide calcification.
CATEGORY B
More health-conscious people. Slow aging with a healthy diet and bone-challenging exercises that keep bones strong, leading to less calcification. The onset of calcium-related degenerative diseases is delayed.
CATEGORY C
With AIC Therapy, thyroid hormone (TH) leads to bone-building that restores calcium homeostasis and leads to body-wide decalcification, which helps to reverse calcium-related degenerative diseases.
STRENGTHENING THE BONE IS A KEY TO A HEALTHY LIFE
“While a calcium deficiency is always present in the bones of individuals with chronic disease and is especially severe in those with osteoporosis, it is precisely the chronic loss of calcium from its large bony reservoir that continually feeds the excess presence of calcium elsewhere in the body.” Dr. Thomas Levy, Cardiologist
HEALTHY BONES PREVENT CALCIUM DYSFUNCTION
“A wide range of Ca2+ signaling systems delivers the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. However, these homeostatic systems are highly plastic and can undergo a process of phenotypic remodeling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals has been linked to some of the major diseases in humans, such as cardiac disease, schizophrenia, bipolar disorder, and Alzheimer's disease.”*
*Calcium signaling remodelling and disease Michael J. Berridge, Biochemical Society TrantionsMar 21, 2012
HEALTHY BONE PREVENTS CALCIUM DYSFUNCTION
“A wide range of Ca2+ signaling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodeling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals has been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder, and Alzheimer's disease.”*
*Calcium signaling remodelling and disease Michael J. Berridge, Biochemical Society TrantionsMar 21, 2012
CELLULAR DE-CALCIFICATION AS HEALING PATHWAYS
“Given its ubiquitous role, it is predictable that a deregulation along any point in the calcium signaling pathway may be capable of disrupting neurological function, which has already been demonstrated by several ‘calciumopathies’ – a diverse group of diseases caused by a disruption of calcium homeostasis.”
(Geert Bultynck and Jan Parys, Department of Physiology and Biophysics, University of California, Irvine, Irvine, CA, USA)
CALCIUM THERAPY IS NOT CALCIUM SUPPLEMENTATION
It is important to consume around 1000mg of calcium daily, ideally through a healthy diet. However, as we age, our digestive power weakens, making it difficult to absorb the necessary calcium. To address this, doctors often recommend calcium supplements that are easier to absorb, thanks to added vitamin D3 and vitamin K2. Nevertheless, some orthomolecular doctors caution against calcium supplementation due to the potential risks of increased calcification and associated health issues, such as heart attacks.
It is worth noting that AIC therapy is not the same as calcium supplementation. While it is still important to consume an adequate amount of calcium, a small amount of 'ionic' calcium can trigger unique health benefits that protein-bound calcium cannot provide. In fact, AIC can even help the body to more effectively utilize inactive protein calcium by activating it and directing it to where it is needed.
Targeting the Secondary Cause of Disease Stops Disease Progression
We are familiar with the primary causes or root causes of disease. It could be toxins like heavy metals, chemicals, or mycotoxins. It could be pathogens like bacteria and viruses. Or it could be genetic disposition or an unhealthy lifestyle that triggers inflammation and oxidative stress. Many doctors focus on eliminating these primary causes as an important part of comprehensive treatment.
However, the research world has identified a secondary cause of diseases that follows the root causes and plays a huge role in accelerating disease progression and amplifying symptoms: ionic calcium signaling dysfunction, also known as calciumopathy. When cellular calcium signaling is compromised, cells act abnormally and also cause mitochondrial dysfunction. Therefore, it has been suggested that protecting cellular homeostasis could prevent the progression of disease. AIC therapy plays an important role in normalizing dysfunctional calcium signaling and restoring correct cell behaviors.
COMPELLING AIC THERAPY RESULTS
Radical bone turnover in animal trial
Animal study done on bone building. The same human dosing calibrated to the animal weight was administered daily for 9 weeks. AIC proved to be 100% more effectively compared to calcium carbonate in bone strength test and bone composition analysis. No match!
Calcium ions in the blood are so vital that the body cannot permit it to fluctuate. Therefore, even a slight increase in ionized calcium concentration in the blood triggers the bone-building process to take excess calcium into bones. Utilizing this process is the most effective and safe way to support strong bones since it follows the body’s natural bone-building mechanism. This amazing effect of AIC was observed in this animal clinical trial through the bone break test, where AIC ‘treated’ bone displayed almost 100% more bone-building power than regular calcium carbonate.
The effects of Antiorbital Ionic Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats are studied. The study revealed that the induced osteoporosis was completely reversed with AIC therapy. Osteocalcin, estradiol, eosinophil, CTx, and BMD levels were elevated with AIC, indicating that optimal bone health is restored.
Values are mean ± SD for five rats. Means with different superscript letters are significantly different at p<0.05 by Duncan’s multiple range tests.
Control: sham operation
OVX: no treatment after Ovariectomy
OVX+AIC: AIC Therapy after Ovariectomy
NOTABLE BONE DENSITY INCREASE IN HUMAN TRIAL
CBHI (Canada) used an FDA-approved ultrasound bone densitometer by BeamMed to measure and compare BMD data from more than 1,000 patients. Over 90% of the patients experienced increased bone density.
Bone Density Recovery
The benefits of AIC therapy extend beyond bone strengthening. Although most calcium is stored in bones, the small amount in the bloodstream plays a critical role in overall health. About 50% of circulating serum calcium is “ionized” (Ca²⁺), the active form recognized by the body for muscle and nerve function, blood clotting, bone maintenance, and cellular signaling.
With aging, ionic calcium homeostasis can become disrupted due to bone deterioration and progressive cellular calcification. AIC therapy may help restore this balance, potentially supporting the body’s defense against over 150 degenerative diseases associated with calcium displacement. Rebuilding bone health may therefore support both fracture prevention and overall cellular health.
SIGNIFICANT BONE DENSITY RISE
A volunteer study conducted at CBHI observed that many postmenopausal women with bone loss showed meaningful improvements in Bone Mineral Density (BMD) after undergoing AIC therapy. In the chart, blue bars represent BMD measurements before therapy, while green bars show BMD levels after treatment, revealing an overall upward trend in bone density among participants.
The X-axis marks the osteopenia borderline, while the Y-axis represents the T-score, a standard clinical measure of bone strength and fracture risk. Overall, several participants moved closer to—or beyond—the osteopenia threshold after therapy, suggesting a potential positive impact of AIC therapy on bone health.
Understanding Calcium Homeostasis
Bone is the major storage site for calcium in the body, and movement of calcium into and out of bone helps determine blood calcium\ levels, which is critical for normal muscle and nervous system function. Calcium (Ca2+) moves into bone as osteoblasts build new bone and out of bone as osteoclasts break down bone. When osteoblast and osteoclast activity is balanced, the movements of calcium into and out of a bone are equal.
When blood calcium levels are too low, osteoclast activity increases, osteoclasts release calcium from bone into the blood, and blood calcium levels increase. Conversely, if blood calcium levels are too high, osteoclast activity decreases, osteoblasts remove calcium from the blood to produce new bone, and blood calcium levels decrease.
The Physiological Balance of Calcium Homeostasis
Calcium homeostasis is maintained by three hormones: parathyroid hormone (PTH) from the parathyroid glands, vitamin D from the skin or diet, and calcitonin from the thyroid gland. PTH and vitamin D are secreted when blood ionic calcium levels are too low, and calcitonin is secreted when blood ionic calcium levels are too high. When serum ionic calcium level is slightly increased by the therapy, the thyroid gland releases calcitonin, which works to decrease blood calcium levels by inhibiting osteoclast activity. Even in the absence of osteoclast activity, osteoblast activity continues, removing calcium from the blood and depositing it into the bone.
In summary, PTH, vitamin D, and calcitonin work together to keep blood calcium levels within the homeostatic range, and this process can be triggered by AIC therapy
It’s all about communication
Ionic calcium level is possibly the most precisely regulated substance out of all the minerals, vitamins, enzymes, and hormones. Many organs including thyroid, parathyroids, kidneys, intestines, and bones are all working together constantly in keeping the calcium level where it needs to be. Even in cellular level, many types calcium channels, mitochondria, and endoplasmic reticulum works constantly to keep intracellular calcium level at where it needs to be. Why? Because of ionic calcium’s role in communication. Precise calcium signaling requires precise levels at different parts of our body,
What is calcium signaling?
Researchers used light-sheet microscopy to form 3-D images of the process in primary cortical neurons from embryonic rats.
Calcium Signaling: From Normal B Cell Development to Tolerance Breakdown and Autoimmunity.
Calcium (Ca2+) signaling and its interacting networks regulate numerous biological processes, including gene expression, excitation-contraction coupling, stimulus-secretion coupling, synaptic transmission, synaptic plasticity, and embryonic development. These signals are generated and decoded through structures, organelles, receptors, channels, calcium-binding proteins, pumps, transporters, enzymes, and transcription factors.
Advanced methods for measuring calcium concentrations, statistical analysis, and biophysical simulations are used to model calcium signaling and study its role in physiological processes and diseases such as cancers, diabetes, and neurodegenerative disorders. Research in Ca2+ signaling also supports drug discovery and helps explain the mechanisms of action of treatments, including calcium channel blockers widely used for hypertension and atrial fibrillation.
Ca2+ signaling is nearly universal in biology, including in bacteria, which use 2-component regulatory systems consisting of a sensor kinase and response element. Studies in model organisms such as Drosophila melanogaster, Saccharomyces cerevisiae, Caenorhabditis elegans, and zebrafish have led to important discoveries. In particular, Ca2+ imaging in zebrafish has improved understanding of development, physiological processes, and disease-related genes in vertebrate systems.
Unique Physical Properties of AIC Calcium
Because of the electrical charge of AIC ionic calcium carbonate molecules that interacts with the hydrogen bonding of water molecules, an open bottle of AIC evaporates calcium together with water molecules and crystallizes with CO2 in the air.
AIC is 200x more soluble in water compared to calcium carbonate and 3x more reactive in chemical reactions.
AIC Therapy health benefits
Cellular Recovery Helps to Restore Mitochondrial Function, Reduce Oxidative Stress, and Correct Cell Signaling, which has
positive benefits for conditions listed here and more.
Autoimmune disease (Lupus, Vitiligo, Hashimoto’s, Crohn’s, Celiac disease, eczema, MS, rheumatoid, etc.)
Lyme disease, HIV, Shingles and other viral infections
Parkinson’s, ALS, Alzheimer’s and other neurodegenerative diseases
Arthritis, Gout, CPPD, Inflammations
Mitochondrial Disease
Cancer (carcinoma, sarcoma, lymphoma, leukemia, multiple myeloma)
Arrhythmia, Heart palpitation, Mitral Valve Prolapse,
Diabetes, Metabolic Syndrome
Thrombosis, Hemolytic Anemia
Autism Spectrum Disorder,
ADHD, Epilepsy
Asthma, COPD
Glaucoma, Cataract, Intermittent Exotropia, Retinal Vein Occlusion
Dysmenorrhea, infertility
Menier’s Disease, Aurora Migraine Disease, Tinnitus, Vertigo
Osteoporosis, Bone Necrosis
Chromosome 8 syndrome
Chronic Kidney Disease
Gum disease, Loose teeth
Calcification (joints and tissues), Calcific tendonitis, Fibrosis, Kidney and Gall Bladder Stones
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