"Discover Dr. Server Bozdogan’s must-read newsletter series—insights every participating physician should have at their fingertips."
Latest Research Highlights – Stay Informed, Stay Ahead.
Arthritis
This newsletter explores how joint pain can begin at the cellular level through calcium misplacement, before inflammation or structural damage is ever visible.
This newsletter reveals how disrupted calcium signaling, not wear or inflammation, keeps joints locked in dysfunction.
Autoimmuine Disease
Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion, cytotoxicity, apoptosis, and numerous gene transcriptions.
This newsletter explores how calcium misregulation drives inflammation and examines therapeutic approaches that reestablish physiological calcium signaling in chronic disease.
This newsletter explores how restoring precise intracellular calcium flow can energize immune cells, strengthen pathogen defense, and improve infection outcomes.
Cellular Health
Clinical resistance isn’t always about protocol failure—it’s sometimes about what lies beneath the surface, unseen.
This newsletter reveals how coffee, when decoded through calcium-regulated pathways, offers precise leverage over energy, cognition, and adaptive stress responses.
Calcium (Ca2+) is not merely a structural component of bones but a dynamic biochemical messenger that orchestrates the intricate processes of wound healing.
This newsletter explores how hidden calcium imbalances silently shape your sleep, mood, inflammation, and long-term health.
Dental Health
Part one explores how calcium regulates alveolar bone stability and cavity prevention.
Part Two focuses on its role in dental implants, bone remodeling, and the prevention of peri-implant resorption while maintaining gingival tissue integrity.
Part Three covers calcium’s impact on gum recession and highlights its role in enamel remineralization, salivary pH balance, and gingival tissue repair.
Detox
The first part of this newsletter series explores calcium’s pivotal contributions to Detoxification and its Impact on Oxidative Stress Management.
This second part focuses on Calcium’s Role in Heavy Metal Detoxification, unraveling how it aids in mitigating toxicity and restoring cellular balance.
This third part probes ionic calcium’s role into Detoxification related to skin health and anti-aging. Together, the series demonstrates how calcium is a cornerstone in safeguarding the body from oxidative stress and toxic challenges.
Diabetes
This newsletter reveals how calcium dysregulation is not a byproduct of type 2 diabetes but a driving force behind β-cell failure, insulin resistance, and early vascular damage—redefining how metabolic dysfunction begins.
Heart Disease
Part one focuses on how ionic calcium regulates heartbeat rhythm, myocardial contraction, and overall cardiac performance.
Part two explores how anxiety disrupts heart function through calcium imbalance and why addressing it is key to cardiovascular
Part three explores how calcium dysregulation contributes to hypertension and stroke risk.
Part four explores the link between calcium imbalance and heart failure.
This newsletter reveals how disordered calcium flow inside the vessel wall drives stiffness and early mineral seeding, and how AIC may help shift tissue behavior toward repair.
Infectious Diseases
This newsletter reveals how disrupted calcium signaling quietly reshapes the cancer terrain long before a tumor forms.
Longevity
This newsletter series, "Cellular Approach to Longevity by Calcium," delves into calcium’s multidimensional influence on health beyond its traditional role in bone strength. The first part explores Calcium: A Key to Cellular Longevity through DNA Repair, Mitochondrial Health, and Telomere Stability.
This newsletter series, "Cellular Approach to Longevity by Calcium," delves into calcium’s multidimensional influence on health beyond its traditional role in bone strength. The second part investigates Calcium's Role in Longevity: Optimizing Bone Health, Cellular Signaling, and Inflammation Control.
This newsletter series, "Cellular Approach to Longevity by Calcium," delves into calcium’s multidimensional influence on health beyond its traditional role in bone strength. This third part brings it all together, highlighting Calcium’s Role in Systemic Communication and Cellular Resilience.
This newsletter reveals how targeted calcium signaling, including AIC-driven pulses, integrates with bile acids, fermentable fibers, and circadian inputs to reset barrier function and motility.
Neurodegenerative Diseases
This is the first part of our four-part series on how AIC Therapy can help prevent and manage neurodegenerative diseases.
Part two examines how AIC Therapy targets the underlying mechanisms of Alzheimer’s and dementia, offering new ways to protect brain function.
Part three focuses on Parkinson's, highlighting how AIC Therapy can help manage disease progression.
Part 4 will cover ALS, discussing how AIC Therapy supports motor neuron health, protects neurons, and improves muscle functions.
This newsletter reveals how sleep disorders may stem not only from neurohormonal imbalance but also from subtle disruptions in ionic calcium signaling — and introduces AIC therapy as a clinically promising mineral-based intervention.
Oncology
This newsletter reveals how disrupted calcium signaling quietly reshapes the cancer terrain long before a tumor forms.
Studies on leukemia treatment aim to target intracellular calcium levels, recognizing their crucial role in cancer cell behavior and survival.
Before myeloma is visible, the body often sends its warning through silence —not in labs, but in calcium flow.
The ability of calcium influx to disrupt the cell cycle and activate apoptosis pathways has highlighted calcium's potential in cancer treatment. However, the effects of calcium on cancer can only be realized through regulating cellular ionic calcium signaling, which can be achieved with Anti-orbital Ionic Calcium (AIC) therapy.
Cancer cells thrive in an acidic microenvironment due to increased glycolysis and lactic acid production. This acidic environment promotes the invasion and metastasis of cancer cells. Anti-Orbital Ionic Calcium (AIC) therapy alters the microenvironment of cancer cells to be more alkaline.
Calcium ion (Ca2+) is a ubiquitous and versatile signaling molecule that regulates a wide array of cellular processes, including proliferation, cell death, migration, and immune response, which are crucial for cancer development.
In cancer cells, calcium signaling is a critical regulator of metabolic processes that support cell survival. It specifically enhances the activity of TCA cycle enzymes, such as isocitrate dehydrogenase and oxoglutarate dehydrogenase, which are vital for producing the metabolic intermediates required for rapid
AIC therapy has demonstrated potential in addressing critical factors in multiple myeloma(MM), offering a novel approach that may influence outcomes in previously unexplored ways.
Osteoporosis
Calcium imbalances directly affect bone resorption and formation processes, indicating that regulating calcium levels is crucial for maintaining bone density and preventing osteoporosis.
In this series on why stronger bones lead to a healthier life, the first part examines how bones regulate the immune system through dynamic interactions with immune cells.
The second part discusses the endocrine role of bones, focusing on osteocalcin's regulation of energy metabolism and its connection to calcium homeostasis.
This newsletter series explores three vital functions of bones that go far beyond their structural role. The third part highlights bones' contribution to systemic pH balance and acid-base regulation.
This newsletter reveals how specific dairy patterns and corrected calcium signaling can curb midlife fat shift while strengthening bone.
Pain
Calcium isn't just present in pain pathways-it's actively shaping them at every level. Pain starts when calcium channels in nociceptors open, allowing an ion surge that triggers action potentials and sets pain in motion.
This newsletter reveals how silent calcium misplacement-not structural failure -can reshape chronic back pain from within.
This newsletter reveals how disturbed calcium handling drives stubborn myalgia and how restoring rhythms improves function.
Psychiatry
Mental fatigue creeps in unnoticed, stealing focus, dulling motivation, and slowing the mind. But what if the key to restoring clarity and energy isn't about pushing harder but about unlocking a fundamental cellular process?
This newsletter reveals how depression can emerge not just from neurotransmitter imbalance, but from blocked intracellular calcium signaling —a deeper disruption in brain cell communication.
This newsletter reveals that restoring calcium flow inside brain cells is a key step toward rebalancing neural circuits, reducing sensory overload, and unlocking meaningful functional improvements in children with autism.
Stem Cell
This newsletter reveals how overlooked calcium dynamics -not the stem cells themselves -often determine whether a regenerative protocol succeeds, stalls, or silently fails.