Enjoy the Collection of Newsletter Articles by Dr. Server Bozdogan to Participating Physicians.
Arthritis
This newsletter explores how joint pain can begin at the cellular level through calcium misplacement, before inflammation or structural damage is ever visible.
This newsletter reveals how disrupted calcium signaling, not wear or inflammation, keeps joints locked in dysfunction.
Autoimmuine Disease
Regulated increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex and crucial effector functions such as metabolism, proliferation, differentiation, antibody and cytokine secretion, cytotoxicity, apoptosis, and numerous gene transcriptions. AIC therapy restores calcium signaling, which is of paramount importance to proper immune function.
Cellular Health
Clinical resistance isn’t always about protocol failure—it’s sometimes about what lies beneath the surface, unseen.
This newsletter reveals how coffee, when decoded through calcium-regulated pathways, offers precise leverage over energy, cognition, and adaptive stress responses.
Calcium (Ca2+) is not merely a structural component of bones but a dynamic biochemical messenger that orchestrates the intricate processes of wound healing.
Dental Health
Part one explores how calcium regulates alveolar bone stability and cavity prevention.
Part Two focuses on its role in dental implants, bone remodeling, and the prevention of peri-implant resorption while maintaining gingival tissue integrity.
Part Three covers calcium’s impact on gum recession and highlights its role in enamel remineralization, salivary pH balance, and gingival tissue repair.
Detox
The first part of this newsletter series explores calcium’s pivotal contributions to Detoxification and its Impact on Oxidative Stress Management.
This second part focuses on Calcium’s Role in Heavy Metal Detoxification, unraveling how it aids in mitigating toxicity and restoring cellular balance.
This third part probes ionic calcium’s role into Detoxification related to skin health and anti-aging. Together, the series demonstrates how calcium is a cornerstone in safeguarding the body from oxidative stress and toxic challenges.
Diabetes
This newsletter reveals how calcium dysregulation is not a byproduct of type 2 diabetes but a driving force behind β-cell failure, insulin resistance, and early vascular damage—redefining how metabolic dysfunction begins.
Heart Disease
Part one focuses on how ionic calcium regulates heartbeat rhythm, myocardial contraction, and overall cardiac performance.
Part four explores the link between calcium imbalance and heart failure.
Part two explores how anxiety disrupts heart function through calcium imbalance and why addressing it is key to cardiovascular health.
Part three explores how calcium dysregulation contributes to hypertension and stroke risk.
Infectious Diseases
This newsletter reveals how disrupted calcium signaling quietly reshapes the cancer terrain long before a tumor forms.
Longevity
This newsletter series, "Cellular Approach to Longevity by Calcium," delves into calcium’s multidimensional influence on health beyond its traditional role in bone strength. The first part explores Calcium: A Key to Cellular Longevity through DNA Repair, Mitochondrial Health, and Telomere Stability.
This newsletter series, "Cellular Approach to Longevity by Calcium," delves into calcium’s multidimensional influence on health beyond its traditional role in bone strength. The second part investigates Calcium's Role in Longevity: Optimizing Bone Health, Cellular Signaling, and Inflammation Control.
This newsletter series, "Cellular Approach to Longevity by Calcium," delves into calcium’s multidimensional influence on health beyond its traditional role in bone strength. This third part brings it all together, highlighting Calcium’s Role in Systemic Communication and Cellular Resilience.
Neurodegenerative Diseases
This is the first part of our four-part series on how AIC Therapy can help prevent and manage neurodegenerative diseases.
Part 4 covers ALS, discussing how AIC Therapy supports motor neuron health, protects neurons, and improves muscle functions.
Part two examines how AIC Therapy targets the underlying mechanisms of Alzheimer’s and dementia, offering new ways to protect brain function.
This newsletter reveals how sleep disorders may stem not only from neurohormonal imbalance but also from subtle disruptions in ionic calcium signaling.
Part three focus on Parkinson's, highlighting how AIC Therapy can help manage disease progression. Finally, Part 4 will cover ALS, discussing how AIC Therapy supports motor neuron health, protects neurons, and improves muscle function.
Oncology
This newsletter reveals how disrupted calcium signaling quietly reshapes the cancer terrain long before a tumor forms.
Studies on leukemia treatment aim to target intracellular calcium levels, recognizing their crucial role in cancer cell behavior and survival.
Before myeloma is visible, the body often sends its warning through silence —not in labs, but in calcium flow.
The ability of calcium influx to disrupt the cell cycle and activate apoptosis pathways has highlighted calcium's potential in cancer treatment. However, the effects of calcium on cancer can only be realized through regulating cellular ionic calcium signaling, which can be achieved with Anti-orbital Ionic Calcium (AIC) therapy.
In cancer cells, calcium signaling is a critical regulator of metabolic processes that support cell survival. It specifically enhances the activity of TCA cycle enzymes, such as isocitrate dehydrogenase and oxoglutarate dehydrogenase, which are vital for producing the metabolic intermediates required for rapid proliferation.
Cancer cells thrive in an acidic microenvironment due to increased glycolysis and lactic acid production. This acidic environment promotes the invasion and metastasis of cancer cells. Anti-Orbital Ionic Calcium (AIC) therapy alters the microenvironment of cancer cells to be more alkaline.
AIC therapy has demonstrated potential in addressing critical factors in multiple myeloma(MM), offering a novel approach that may influence outcomes in previously unexplored ways.
Calcium ion (Ca2+) is a ubiquitous and versatile signaling molecule that regulates a wide array of cellular processes, including proliferation, cell death, migration, and immune response, which are crucial for cancer development.
Osteoporosis
Calcium imbalances directly affect bone resorption and formation processes, indicating that regulating calcium levels is crucial for maintaining bone density and preventing osteoporosis.
The third part highlights bones' contribution to systemic pH balance and acid-base regulation.
In this series on why stronger bones lead to a healthier life, the first part examines how bones regulate the immune system through dynamic interactions with immune cells.
In the fight against osteoporosis, AIC Therapy leverages the body's production of calcitonin to combat osteoporosis effectively.
The second part discusses the endocrine role of bones, focusing on osteocalcin's regulation of energy metabolism and its connection to calcium homeostasis.
Pain
Calcium isn't just present in pain pathways-it's actively shaping them at every level. Pain starts when calcium channels in nociceptors open, allowing an ion surge that triggers action potentials and sets pain in motion.
This newsletter reveals how silent calcium misplacement-not structural failure -can reshape chronic back pain from within.
Physiciatri
Mental fatigue creeps in unnoticed, stealing focus, dulling motivation, and slowing the mind. But what if the key to restoring clarity and energy isn't about pushing harder but about unlocking a fundamental cellular process?
This newsletter reveals how depression can emerge not just from neurotransmitter imbalance, but from blocked intracellular calcium signaling —a deeper disruption in brain cell communication.
This newsletter reveals that restoring calcium flow inside brain cells is a key step toward rebalancing neural circuits, reducing sensory overload, and unlocking meaningful functional improvements in children with autism.
Stem Cell
This newsletter reveals how overlooked calcium dynamics -not the stem cells themselves -often determine whether a regenerative protocol succeeds, stalls, or silently fails.