0
Mean BMD increase (Moffitt, 135 subjects)
0
Osteopenic returned to normal density
0
Osteoporotic reached normal density
0
Subject Asian-population cohort
Scientific studies on AIC

Studies on AIC.

Our latest studies and findings, from clinical case reports to conference presentations.

Illustration of systemic calcium signaling across bone, blood vessels, and joints
Case report · Multiple myeloma

Sustained Deep Biochemical Response in Multiple Myeloma Managed with AIC Therapy: A Two-Year Case Report

A woman in her late 60s with IgG-lambda multiple myeloma reached deep remission on AIC alongside targeted therapy, with M-spike, IgG, and free light chains falling and kidney function and anemia recovering. By April 2026 all targeted drugs were discontinued, with disease stable on AIC alone.

Speaking engagements

Speaking Engagements in Recent Conferences.

Talks and abstracts our team and collaborators have presented at recent scientific meetings.

ASBMR 2025, Seattle: Efficacy of AIC (antiorbital calcium carbonate) on bone density among the Asian population, presented September 6th by Dr. Jong Park, Moffitt Cancer Center ASBMR 2025, Seattle: Pretreatment of bone anabolic agent delays or prevents myeloma progression, presented September 7th by Dr. Donghoon Yoon, Rockefeller Cancer Institute AACR 2025, Chicago: Pretreatment of bone anabolic agent delays or prevents myeloma progression, presented April 26th by Dr. Donghoon Yoon, Rockefeller Cancer Institute
Research library by condition

Explore the literature.

Published articles on ionic calcium and disease, organized by area. Filter by condition to browse.

Showing 75 of 75 articles

A Paradigm Shift in Bone Health
Other Research

A Paradigm Shift in Bone Health

Retrospective clinical findings show Antiorbital Ionic Calcium significantly improved bone density and osteoporosis outcomes in an 82-patient cohort over eight months.

Re-engineering the Bone Microenvironment
Other Research

Re-engineering the Bone Microenvironment

AIC may help slow multiple myeloma progression by strengthening the bone microenvironment; preclinical models showed delayed tumor development and improved survival.

Rewriting the Cancer
Other Research

Rewriting the Cancer

Restoring calcium homeostasis may help normalize the cancer microenvironment, reducing inflammation and suppressing pathways that support tumor growth and metastasis.

Calcium and Apoptosis
Oncology

Calcium and Apoptosis

Malignant tumors arise from deregulated proliferation or an inability of cells to undergo apoptotic cell death, in which calcium plays a central regulatory role.

Calcium Homeostasis in Cancer: A Focus on Senescence
Oncology

Calcium Homeostasis in Cancer: A Focus on Senescence

Senescence is a primary anti-tumorigenic response to oncoprotein activation, and calcium plays a major role in the pathways that control it.

Calcium Signaling in Lung Cancer
Oncology

Calcium Signaling in Lung Cancer

Calcium is a ubiquitous cellular signal that is crucial in cancer; altered Ca2+ channels and binding proteins are characterizing features of lung cancer.

The Pathways of Cell Death: Oncosis, Apoptosis, and Necrosis
Oncology

The Pathways of Cell Death

A review of how cells die after lethal injury, distinguishing oncosis, apoptosis, and necrosis, central to diagnostic and research pathology.

Store-Independent Ca2+ Entry and the DNA Damage Response in Breast Cancer
Oncology

Store-Independent Ca2+ Entry and the DNA Damage Response in Breast Cancer

Most estrogen-receptor-positive tumors express wild-type p53; store-independent calcium entry helps regulate their DNA damage response.

Where Cancer Meets Calcium: p53 Crosstalk with EF-hands
Oncology

Where Cancer Meets Calcium: p53 Crosstalk with EF-hands

Calcium is a ubiquitous second messenger; S100 EF-hand calcium-binding proteins crosstalk with the p53 tumor-suppressor pathway.

Activated AKT Regulates NF-kB and p53 Inhibition in HTLV-1 Cells
Oncology

Activated AKT Regulates NF-kB and p53 Inhibition in HTLV-1 Cells

AKT activation enhances resistance to apoptosis in HTLV-1-transformed cells, driving NF-kB activation and p53 inhibition through downstream survival signalling.

Glucose Metabolism, Lactate, and Ammonia Production by the Human Placenta
Oncology

Glucose Metabolism, Lactate, and Ammonia Production by the Human Placenta

Fifteen human term placentas incubated in vitro, measuring glucose consumption against lactate and ammonia output in placental tissue.

ATP Depletion and Cancer Cell Death after Calcium Electroporation
Oncology

ATP Depletion and Cancer Cell Death after Calcium Electroporation

Calcium electroporation kills cancer cells in a dose-dependent manner, with the effect tracking both calcium concentration and electric field strength.

Calcium, Magnesium, and Colorectal Cancer
Oncology

Calcium, Magnesium, and Colorectal Cancer

A study of dietary calcium and magnesium intake and their combined association with colorectal cancer risk.

Calcium, Calcineurin, and the Control of Transcription
Oncology

Calcium, Calcineurin, and the Control of Transcription

Calcineurin, a calcium-activated phosphatase, links cytosolic calcium signals to the transcriptional programmes that determine cell fate.

Vitamin D, Calcium, and Retinol Intake and Pancreatic Cancer
Oncology

Vitamin D, Calcium, and Retinol Intake and Pancreatic Cancer

A population-based case-control study in the San Francisco Bay area evaluating dietary vitamin D, calcium, and retinol against pancreatic cancer risk.

Dairy Products, Calcium Intake, and Prostate Cancer Risk
Oncology

Dairy Products, Calcium Intake, and Prostate Cancer Risk

In the Physicians' Health Study cohort, high calcium intake from dairy may raise prostate cancer risk by lowering circulating 1,25-dihydroxyvitamin D3.

Calcium Electroporation in Three Cell Lines
Oncology

Calcium Electroporation in Three Cell Lines

A comparison of bleomycin against calcium, of different calcium compounds, and of pulsing conditions across three cell lines.

Calcium Electroporation to Induce Tumor Necrosis
Oncology

Calcium Electroporation to Induce Tumor Necrosis

Electroporation with isotonic calcium permeabilises cell membranes and achieves highly effective cancer cell death in tumour tissue.

Calcium Signaling and the Therapeutic Targeting of Cancer Cells
Oncology

Calcium Signaling and the Therapeutic Targeting of Cancer Cells

How altered calcium channels and pumps in cancer cells create openings for cytotoxic therapy, and how they contribute to treatment resistance.

The Molecular Era of the Mitochondrial Calcium Uniporter
Oncology

The Molecular Era of the Mitochondrial Calcium Uniporter

Mitochondria are among the most important regulators and targets of calcium signalling; the uniporter is the channel through which that traffic passes.

Calcium, Cancer, and Killing by Cytotoxic T and NK Cells
Oncology

Calcium, Cancer, and Killing by Cytotoxic T and NK Cells

The role of calcium and ORAI channels in how cytotoxic T lymphocytes and natural killer cells destroy cancer cells.

Cancer-Generated Lactic Acid: An Immunosuppressive Metabolite?
Oncology

Cancer-Generated Lactic Acid: An Immunosuppressive Metabolite?

An invited review arguing that lactic acid produced by tumours acts as a regulatory, immunosuppressive signal rather than a metabolic by-product.

Regulation of Wild-Type p53 by S100B and Calcium-Dependent Protein Kinase C
Oncology

Regulation of Wild-Type p53 by S100B and Calcium-Dependent Protein Kinase C

S100B and calcium-dependent protein kinase C jointly govern the nuclear accumulation and activation of wild-type p53.

Diet-Induced Acidosis and Cancer
Oncology

Diet-Induced Acidosis and Cancer

Acidogenic diets high in animal protein and salt can produce low-grade metabolic acidosis, prompting questions about acidosis in cancer risk.

The Role of Calcium in Human Lymphocyte DNA Repair
Oncology

The Role of Calcium in Human Lymphocyte DNA Repair

DNA repair ability falls in a range of pathologic conditions that also disturb cellular calcium homeostasis; this study tests the link directly.

Papillomavirus E6 Oncoproteins and a Calcium-Binding Protein
Oncology

Papillomavirus E6 Oncoproteins and a Calcium-Binding Protein

HPV E6 binds E6BP, a putative calcium-binding protein identical to ERC-55 localised in the endoplasmic reticulum, alongside its p53 interaction.

Interplay of p53 and DNA-Repair Protein XRCC4 in Tumorigenesis
Oncology

Interplay of p53 and DNA-Repair Protein XRCC4 in Tumorigenesis

p53 deficiency rescues the embryonic lethality of XRCC4 loss, revealing how repair failure and p53 status combine in genomic stability.

Bendable Electrochemical Lactate Sensor Printed with Silver Nanoparticles
Oncology

Bendable Electrochemical Lactate Sensor Printed with Silver Nanoparticles

A flexible amperometric lactate biosensor built on printed silver-nanoparticle electrodes, durable enough to survive repeated bending.

Mechanisms of p53-Dependent Apoptosis
Oncology

Mechanisms of p53-Dependent Apoptosis

Growth factor deprivation, DNA damage, and oncogene expression all stabilise and activate p53, which then commits the cell to death.

p53-Mediated DNA Repair Responses to UV Radiation
Oncology

p53-Mediated DNA Repair Responses to UV Radiation

Studies in mouse cells lacking p53, p21, and gadd45 genes, separating each gene's contribution to the repair response after UV damage.

Transcriptional Cross Talk between NF-kB and p53
Oncology

Transcriptional Cross Talk between NF-kB and p53

The two transcription factors regulate one another directly, so that the balance between survival and death signalling is set by their interaction.

p53 at the Endoplasmic Reticulum Regulates Apoptosis via Calcium
Oncology

p53 at the Endoplasmic Reticulum Regulates Apoptosis via Calcium

A pool of p53 resident at the endoplasmic reticulum controls apoptosis specifically through calcium transfer to the mitochondria.

p53-Dependent DNA Repair and Apoptosis at High and Low UV Doses
Oncology

p53-Dependent DNA Repair and Apoptosis at High and Low UV Doses

Repair and apoptosis are both p53-dependent yet respond differently to radiation dose, indicating separable downstream branches.

The p53 Response to DNA Damage
Oncology

The p53 Response to DNA Damage

A review of how p53, normally held at low levels by MDM2-directed degradation, is stabilised and activated once DNA damage is detected.

p53: Good Cop / Bad Cop
Oncology

p53: Good Cop / Bad Cop

A minireview on the cost of p53 activity: the same tumour suppression that protects against cancer carries consequences for ageing.

PI3-Kinase/Akt in Acute Myeloid Leukaemia Survival and Chemoresistance
Oncology

PI3-Kinase/Akt in Acute Myeloid Leukaemia Survival and Chemoresistance

PI3-kinase/Akt is constitutively active in primary AML cells, regulating survival and chemoresistance via NF-kB, MAP kinase, and p53 pathways.

NF-kB and p53 in the Glutamate-Induced Pro-Apoptotic Neuronal Pathway
Oncology

NF-kB and p53 in the Glutamate-Induced Pro-Apoptotic Neuronal Pathway

A review of the possible roles of NF-kB and p53 in the neuronal cell death triggered by glutamate excitotoxicity.

Proteins of the S100 Family Regulate p53 Oligomerization
Oncology

Proteins of the S100 Family Regulate p53 Oligomerization

S100B is elevated in early Alzheimer's brains and S100A4 tracks with metastasis; both regulate how the p53 tumour suppressor assembles.

Concurrent Radiation and Calcium in Two Cancer Cell Lines
Oncology

Concurrent Radiation and Calcium in Two Cancer Cell Lines

A master's thesis from Lund University testing whether calcium administered alongside radiation changes the response of two cancer cell lines.

Recognition of p53 and Other Targets by the Calcium-Binding Protein S100B
Oncology

Recognition of p53 and Other Targets by the Calcium-Binding Protein S100B

How the calcium-binding protein S100B recognises the p53 tumour suppressor and its other protein binding partners.

Role of NF-kB in p53-Mediated Programmed Cell Death
Oncology

Role of NF-kB in p53-Mediated Programmed Cell Death

p53 activation of NF-kB DNA-binding is required for p53 to induce apoptosis, separating its death function from cell-cycle arrest.

The Calcium-Sensing Receptor in Parathyroid Gland Physiology
Oncology

The Calcium-Sensing Receptor in Parathyroid Gland Physiology

An invited review of how the calcium-sensing receptor lets the parathyroid gland read serum calcium and set hormone output accordingly.

Switching p53 States by Calcium: Dynamics of Stress Systems
Oncology

Switching p53 States by Calcium: Dynamics of Stress Systems

A model integrating calcium signalling with the p53-Mdm2 oscillator, studied both deterministically and stochastically.

The Role of the p53 Tumour-Suppressor Gene in Tumorigenesis
Oncology

The Role of the p53 Tumour-Suppressor Gene in Tumorigenesis

The 1993 Walter Hubert Lecture: p53 is mutated in 60% of human tumours, and its product suppresses cell division through transactivation.

Tumour Suppression by p53: A Role for the DNA Damage Response?
Oncology

Tumour Suppression by p53: A Role for the DNA Damage Response?

p53 acts as a barrier to tumour development, and that barrier is disabled in most human cancers through TP53 mutation or pathway alteration.

Calcium Signalling and Calcium Transport in Bone Disease
Osteoporosis

Calcium Signalling and Transport in Bone Disease

Calcium transport and signalling mechanisms in bone cells, many discovered through the study of diseases with disordered bone metabolism.

High-Dose Vitamin D and Calcium Attenuate Bone Loss with Antiretroviral Therapy
Osteoporosis

High-Dose Vitamin D and Calcium Attenuate Bone Loss with ART

As antiretroviral therapy made HIV a chronic illness, osteoporosis and fragility fractures rose; high-dose vitamin D and calcium attenuate that loss.

Anti-Bonding Calcium Carbonate in Ovariectomy-Induced Osteoporosis
Osteoporosis

Anti-Bonding Calcium Carbonate in Ovariectomy-Induced Osteoporosis

A rat study evaluating Sigma Anti-bonding Molecule Calcium Carbonate (the research name for AIC) as a therapy for ovariectomy-induced osteoporosis.

Calcium Signaling and Synaptic Plasticity in Alzheimer's Disease
Neurodegenerative

Calcium Signaling and Synaptic Plasticity in Alzheimer's

Alzheimer's and aging impair memory storage; presenilin-1 mutations disrupt hippocampal long-term potentiation through calcium signaling.

Calcium, Mitochondria, and the Pathogenesis of ALS
Neurodegenerative

Calcium, Mitochondria, and the Pathogenesis of ALS

ALS is marked by the progressive loss of motor neurons; mitochondrial calcium handling is central to its pathogenesis.

Dysregulation of Neuronal Calcium Homeostasis in Alzheimer's Disease
Neurodegenerative

Dysregulation of Neuronal Calcium Homeostasis in Alzheimer's

Synaptic loss drives memory defects in Alzheimer's; deranged neuronal calcium signaling is a therapeutic opportunity.

Calcium and the Inflammatory Response in Multiple Sclerosis
Neurodegenerative

Calcium and the Inflammatory Response in Multiple Sclerosis

MS is a chronic inflammatory disease of the CNS; ionic conductances regulate the T-cell activation and neuronal function involved.

Calcium Signaling Abnormalities in Presymptomatic Alzheimer's Mice
Neurodegenerative

Calcium Signaling Abnormalities in Presymptomatic Alzheimer's Mice

Early pre- and postsynaptic calcium signalling abnormalities mask an underlying synaptic depression before Alzheimer's symptoms appear.

Residual Calcium in Synaptic Depression and Posttetanic Potentiation
Neurodegenerative

Residual Calcium in Synaptic Depression and Posttetanic Potentiation

Fast and slow calcium signalling in nerve terminals, and how residual calcium shapes both synaptic depression and potentiation.

Calcium Signaling and Long-Term Depression in Cerebellar Purkinje Cells
Neurodegenerative

Calcium Signaling and Long-Term Depression in Cerebellar Purkinje Cells

Modelling and simulation of the calcium signalling events that precede long-term depression of synaptic activity in Purkinje cells.

Ionic Calcium and Phosphate in Periodontal Ligament Cells
Dental Health

Ionic Calcium and Phosphate in Periodontal Ligament Cells

How local release of calcium and phosphate ions affects the proliferation, osteogenic differentiation, and mineralization of human periodontal ligament cells.

Myocardial Calcium Signalling in the Heart
Heart Diseases

Myocardial Calcium Signalling in the Heart

Calcium signalling is vital to normal heart function, serving as the primary component of excitation-contraction coupling.

Calcium and Cardiac Arrhythmia
Heart Diseases

Calcium and Cardiac Arrhythmia

Disrupted intracellular calcium dynamics in cardiac cells are an important contributor to life-threatening ventricular arrhythmia.

Calcium and Diabetes
Diabetes

Calcium and Diabetes

Hyperglycemia affects nearly all body systems; altered calcium flux may impair insulin secretion, itself a calcium-dependent process.

Bone Mineral Density in HIV-Infected Patients
Infectious Diseases

Bone Mineral Density in HIV-Infected Patients

Decreased bone mineral density is prevalent in HIV; the efficacy and safety of bisphosphonates in these patients remains unclear.

Alendronate, Vitamin D, and Calcium for Osteoporosis in HIV
Infectious Diseases

Alendronate, Vitamin D, and Calcium for Osteoporosis in HIV

A 48-week randomized study evaluating alendronate with vitamin D and calcium for osteopenia and osteoporosis associated with HIV infection.

Calcium and Lyme Disease
Infectious Diseases

Calcium and Lyme Disease

Lyme borreliosis, transmitted by tick-borne Borrelia burgdorferi, can lead to cardiac, neurological, and inflammatory disorders linked to oxidative stress.

Hypocalcaemia in HIV Infection and AIDS
Infectious Diseases

Hypocalcaemia in HIV Infection and AIDS

Reduced calcium levels in HIV and AIDS have been under-reported and often attributed to hypoalbuminaemia or pharmacotherapy.

Dietary Calcium, Dairy Intake, and Metabolic Abnormalities in HIV
Infectious Diseases

Dietary Calcium, Dairy Intake, and Metabolic Abnormalities in HIV

The health profile of HIV-infected individuals now often includes dyslipidaemia and insulin resistance; this paper examines dietary calcium against those changes.

Calcium Phosphate-Mediated RNA Uptake and Transfer of Cellular Immunity
Infectious Diseases

Calcium Phosphate-Mediated RNA Uptake and Transfer of Cellular Immunity

Calcium phosphate-mediated uptake of exogenous RNA transfers cellular immunity to a synthetic HIV-1 peptide in human lymphocytes.

Intracellular Calcium and Cell Differentiation
Arthritis & Stem Cells

Intracellular Calcium and Cell Differentiation

Changes in intracellular calcium concentration deeply affect the differentiation of non-excitable cells, including elements of the vertebrate skeleton.

Calcium Signalling in Osteoarthritis
Arthritis & Stem Cells

Calcium Signalling in Osteoarthritis

Osteoarthritis gradually destroys articular cartilage; its rising prevalence tracks with increasing life expectancy and obesity.

Mesenchymal Stem Cells and Chondrogenesis
Arthritis & Stem Cells

Mesenchymal Stem Cells and Chondrogenesis

Undifferentiated mesenchymal stem cells are a key source for cell-based cartilage regeneration through chondrogenic differentiation.

Mitochondrial Calcium in Stem Cells
Arthritis & Stem Cells

Mitochondrial Calcium in Stem Cells

Mitochondria buffer intracellular calcium transients; the protein Miro helps regulate mitochondrial calcium homeostasis in cell survival.

Mesenchymal Stem Cells: Key Players in Cancer Progression
Arthritis & Stem Cells

Mesenchymal Stem Cells: Key Players in Cancer Progression

Tumour progression depends on the interaction between tumour cells and the surrounding microenvironment, in which mesenchymal stem cells are active participants.

Mesenchymal Stem Cells Develop Tumor Tropism in Breast Cancer
Arthritis & Stem Cells

Mesenchymal Stem Cells Develop Tumor Tropism in Breast Cancer

In a somatic mouse breast cancer model, mesenchymal stem cells home to the tumour but do not accelerate tumorigenesis.

Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice
Arthritis & Stem Cells

Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice

Mesenchymal stem cells recruited to the gut promote the formation of colorectal tumours in a mouse model.

SAC: Insufficient Intracellular Calcium and Stem Cell Inactivation
Arthritis & Stem Cells

SAC: Insufficient Intracellular Calcium and Stem Cell Inactivation

Insufficient intracellular calcium causes mitochondrial dysfunction and inactivates mesenchymal stem cells; an abstract introducing SAC, the research name for AIC, for aging-related degenerative disease.

Repetitive Ionomycin Treatment in Bovine Nuclear Transfer Embryos
Arthritis & Stem Cells

Repetitive Ionomycin Treatment in Bovine Nuclear Transfer Embryos

Effects of repeated ionomycin-induced calcium influx on the in vitro development of bovine somatic cell nuclear transfer embryos.

Stem Cells and Calcium Signaling
Arthritis & Stem Cells

Stem Cells and Calcium Signaling

A review of how calcium signalling governs stem cell self-renewal, differentiation, and fate across tissue types.

Notice: the research articles above are shared here for your convenience and information only. The same articles can be found through PubMed or NIH. ACRI is not directly involved in this research and is not making any claims.

Collaboration

Open to clinical-trial collaboration and research partnership.

In collaboration with Moffitt Cancer Center, the UAMS Rockefeller Cancer Institute, and the Calcium & Bone Health Institute. Industry partners, institutional research groups, and grant-ready consortia are invited to reach out.

Propose a collaboration

These statements have not been evaluated by the Food and Drug Administration. Antiorbital Ionic Calcium is not intended to diagnose, treat, cure, or prevent any disease. Research is ongoing and outcomes vary.