One place for clinical studies, case reports, conference presentations, and a research library by condition. Our work asks not how much calcium, but where it is directed once inside.
Our latest studies and findings, from clinical case reports to conference presentations.
Published articles on ionic calcium and disease, organized by area. Filter by condition to browse.
Showing 28 of 28 articles

Retrospective clinical findings show Antiorbital Ionic Calcium significantly improved bone density and osteoporosis outcomes in an 82-patient cohort over eight months.

AIC may help slow multiple myeloma progression by strengthening the bone microenvironment; preclinical models showed delayed tumor development and improved survival.

Restoring calcium homeostasis may help normalize the cancer microenvironment, reducing inflammation and suppressing pathways that support tumor growth and metastasis.

Malignant tumors arise from deregulated proliferation or an inability of cells to undergo apoptotic cell death, in which calcium plays a central regulatory role.

Senescence is a primary anti-tumorigenic response to oncoprotein activation, and calcium plays a major role in the pathways that control it.

Calcium is a ubiquitous cellular signal that is crucial in cancer; altered Ca2+ channels and binding proteins are characterizing features of lung cancer.

A review of how cells die after lethal injury, distinguishing oncosis, apoptosis, and necrosis, central to diagnostic and research pathology.

Most estrogen-receptor-positive tumors express wild-type p53; store-independent calcium entry helps regulate their DNA damage response.

Calcium is a ubiquitous second messenger; S100 EF-hand calcium-binding proteins crosstalk with the p53 tumor-suppressor pathway.

Calcium transport and signalling mechanisms in bone cells, many discovered through the study of diseases with disordered bone metabolism.

As antiretroviral therapy made HIV a chronic illness, osteoporosis and fragility fractures rose; high-dose vitamin D and calcium attenuate that loss.

A rat study evaluating Sigma Anti-bonding Molecule Calcium Carbonate (the research name for AIC) as a therapy for ovariectomy-induced osteoporosis.

Alzheimer's and aging impair memory storage; presenilin-1 mutations disrupt hippocampal long-term potentiation through calcium signaling.

ALS is marked by the progressive loss of motor neurons; mitochondrial calcium handling is central to its pathogenesis.

Synaptic loss drives memory defects in Alzheimer's; deranged neuronal calcium signaling is a therapeutic opportunity.

MS is a chronic inflammatory disease of the CNS; ionic conductances regulate the T-cell activation and neuronal function involved.

How local release of calcium and phosphate ions affects the proliferation, osteogenic differentiation, and mineralization of human periodontal ligament cells.

Calcium signalling is vital to normal heart function, serving as the primary component of excitation-contraction coupling.

Disrupted intracellular calcium dynamics in cardiac cells are an important contributor to life-threatening ventricular arrhythmia.

Hyperglycemia affects nearly all body systems; altered calcium flux may impair insulin secretion, itself a calcium-dependent process.

Decreased bone mineral density is prevalent in HIV; the efficacy and safety of bisphosphonates in these patients remains unclear.

A 48-week randomized study evaluating alendronate with vitamin D and calcium for osteopenia and osteoporosis associated with HIV infection.

Lyme borreliosis, transmitted by tick-borne Borrelia burgdorferi, can lead to cardiac, neurological, and inflammatory disorders linked to oxidative stress.

Reduced calcium levels in HIV and AIDS have been under-reported and often attributed to hypoalbuminaemia or pharmacotherapy.

Changes in intracellular calcium concentration deeply affect the differentiation of non-excitable cells, including elements of the vertebrate skeleton.

Osteoarthritis gradually destroys articular cartilage; its rising prevalence tracks with increasing life expectancy and obesity.

Undifferentiated mesenchymal stem cells are a key source for cell-based cartilage regeneration through chondrogenic differentiation.

Mitochondria buffer intracellular calcium transients; the protein Miro helps regulate mitochondrial calcium homeostasis in cell survival.
Notice: the research articles above are shared here for your convenience and information only. The same articles can be found through PubMed or NIH. ACRI is not directly involved in this research and is not making any claims.
In collaboration with Moffitt Cancer Center, the UAMS Rockefeller Cancer Institute, and the Calcium & Bone Health Institute. Industry partners, institutional research groups, and grant-ready consortia are invited to reach out.
Propose a collaborationThese statements have not been evaluated by the Food and Drug Administration. Antiorbital Ionic Calcium is not intended to diagnose, treat, cure, or prevent any disease. Research is ongoing and outcomes vary.