One place for clinical studies, case reports, conference presentations, and a research library by condition. Our work asks not how much calcium, but where it is directed once inside.
Our latest studies and findings, from clinical case reports to conference presentations.
Published articles on ionic calcium and disease, organized by area. Filter by condition to browse.
Showing 75 of 75 articles

Retrospective clinical findings show Antiorbital Ionic Calcium significantly improved bone density and osteoporosis outcomes in an 82-patient cohort over eight months.

AIC may help slow multiple myeloma progression by strengthening the bone microenvironment; preclinical models showed delayed tumor development and improved survival.

Restoring calcium homeostasis may help normalize the cancer microenvironment, reducing inflammation and suppressing pathways that support tumor growth and metastasis.

Malignant tumors arise from deregulated proliferation or an inability of cells to undergo apoptotic cell death, in which calcium plays a central regulatory role.

Senescence is a primary anti-tumorigenic response to oncoprotein activation, and calcium plays a major role in the pathways that control it.

Calcium is a ubiquitous cellular signal that is crucial in cancer; altered Ca2+ channels and binding proteins are characterizing features of lung cancer.

A review of how cells die after lethal injury, distinguishing oncosis, apoptosis, and necrosis, central to diagnostic and research pathology.

Most estrogen-receptor-positive tumors express wild-type p53; store-independent calcium entry helps regulate their DNA damage response.

Calcium is a ubiquitous second messenger; S100 EF-hand calcium-binding proteins crosstalk with the p53 tumor-suppressor pathway.

AKT activation enhances resistance to apoptosis in HTLV-1-transformed cells, driving NF-kB activation and p53 inhibition through downstream survival signalling.

Fifteen human term placentas incubated in vitro, measuring glucose consumption against lactate and ammonia output in placental tissue.

Calcium electroporation kills cancer cells in a dose-dependent manner, with the effect tracking both calcium concentration and electric field strength.

A study of dietary calcium and magnesium intake and their combined association with colorectal cancer risk.

Calcineurin, a calcium-activated phosphatase, links cytosolic calcium signals to the transcriptional programmes that determine cell fate.

A population-based case-control study in the San Francisco Bay area evaluating dietary vitamin D, calcium, and retinol against pancreatic cancer risk.

In the Physicians' Health Study cohort, high calcium intake from dairy may raise prostate cancer risk by lowering circulating 1,25-dihydroxyvitamin D3.

A comparison of bleomycin against calcium, of different calcium compounds, and of pulsing conditions across three cell lines.

Electroporation with isotonic calcium permeabilises cell membranes and achieves highly effective cancer cell death in tumour tissue.

How altered calcium channels and pumps in cancer cells create openings for cytotoxic therapy, and how they contribute to treatment resistance.

Mitochondria are among the most important regulators and targets of calcium signalling; the uniporter is the channel through which that traffic passes.

The role of calcium and ORAI channels in how cytotoxic T lymphocytes and natural killer cells destroy cancer cells.

An invited review arguing that lactic acid produced by tumours acts as a regulatory, immunosuppressive signal rather than a metabolic by-product.

S100B and calcium-dependent protein kinase C jointly govern the nuclear accumulation and activation of wild-type p53.

Acidogenic diets high in animal protein and salt can produce low-grade metabolic acidosis, prompting questions about acidosis in cancer risk.

DNA repair ability falls in a range of pathologic conditions that also disturb cellular calcium homeostasis; this study tests the link directly.

HPV E6 binds E6BP, a putative calcium-binding protein identical to ERC-55 localised in the endoplasmic reticulum, alongside its p53 interaction.

p53 deficiency rescues the embryonic lethality of XRCC4 loss, revealing how repair failure and p53 status combine in genomic stability.

A flexible amperometric lactate biosensor built on printed silver-nanoparticle electrodes, durable enough to survive repeated bending.

Growth factor deprivation, DNA damage, and oncogene expression all stabilise and activate p53, which then commits the cell to death.

Studies in mouse cells lacking p53, p21, and gadd45 genes, separating each gene's contribution to the repair response after UV damage.

The two transcription factors regulate one another directly, so that the balance between survival and death signalling is set by their interaction.

A pool of p53 resident at the endoplasmic reticulum controls apoptosis specifically through calcium transfer to the mitochondria.

Repair and apoptosis are both p53-dependent yet respond differently to radiation dose, indicating separable downstream branches.

A review of how p53, normally held at low levels by MDM2-directed degradation, is stabilised and activated once DNA damage is detected.

A minireview on the cost of p53 activity: the same tumour suppression that protects against cancer carries consequences for ageing.

PI3-kinase/Akt is constitutively active in primary AML cells, regulating survival and chemoresistance via NF-kB, MAP kinase, and p53 pathways.

A review of the possible roles of NF-kB and p53 in the neuronal cell death triggered by glutamate excitotoxicity.

S100B is elevated in early Alzheimer's brains and S100A4 tracks with metastasis; both regulate how the p53 tumour suppressor assembles.

A master's thesis from Lund University testing whether calcium administered alongside radiation changes the response of two cancer cell lines.

How the calcium-binding protein S100B recognises the p53 tumour suppressor and its other protein binding partners.

p53 activation of NF-kB DNA-binding is required for p53 to induce apoptosis, separating its death function from cell-cycle arrest.

An invited review of how the calcium-sensing receptor lets the parathyroid gland read serum calcium and set hormone output accordingly.

A model integrating calcium signalling with the p53-Mdm2 oscillator, studied both deterministically and stochastically.

The 1993 Walter Hubert Lecture: p53 is mutated in 60% of human tumours, and its product suppresses cell division through transactivation.

p53 acts as a barrier to tumour development, and that barrier is disabled in most human cancers through TP53 mutation or pathway alteration.

Calcium transport and signalling mechanisms in bone cells, many discovered through the study of diseases with disordered bone metabolism.

As antiretroviral therapy made HIV a chronic illness, osteoporosis and fragility fractures rose; high-dose vitamin D and calcium attenuate that loss.

A rat study evaluating Sigma Anti-bonding Molecule Calcium Carbonate (the research name for AIC) as a therapy for ovariectomy-induced osteoporosis.

Alzheimer's and aging impair memory storage; presenilin-1 mutations disrupt hippocampal long-term potentiation through calcium signaling.

ALS is marked by the progressive loss of motor neurons; mitochondrial calcium handling is central to its pathogenesis.

Synaptic loss drives memory defects in Alzheimer's; deranged neuronal calcium signaling is a therapeutic opportunity.

MS is a chronic inflammatory disease of the CNS; ionic conductances regulate the T-cell activation and neuronal function involved.

Early pre- and postsynaptic calcium signalling abnormalities mask an underlying synaptic depression before Alzheimer's symptoms appear.

Fast and slow calcium signalling in nerve terminals, and how residual calcium shapes both synaptic depression and potentiation.

Modelling and simulation of the calcium signalling events that precede long-term depression of synaptic activity in Purkinje cells.

How local release of calcium and phosphate ions affects the proliferation, osteogenic differentiation, and mineralization of human periodontal ligament cells.

Calcium signalling is vital to normal heart function, serving as the primary component of excitation-contraction coupling.

Disrupted intracellular calcium dynamics in cardiac cells are an important contributor to life-threatening ventricular arrhythmia.

Hyperglycemia affects nearly all body systems; altered calcium flux may impair insulin secretion, itself a calcium-dependent process.

Decreased bone mineral density is prevalent in HIV; the efficacy and safety of bisphosphonates in these patients remains unclear.

A 48-week randomized study evaluating alendronate with vitamin D and calcium for osteopenia and osteoporosis associated with HIV infection.

Lyme borreliosis, transmitted by tick-borne Borrelia burgdorferi, can lead to cardiac, neurological, and inflammatory disorders linked to oxidative stress.

Reduced calcium levels in HIV and AIDS have been under-reported and often attributed to hypoalbuminaemia or pharmacotherapy.

The health profile of HIV-infected individuals now often includes dyslipidaemia and insulin resistance; this paper examines dietary calcium against those changes.

Calcium phosphate-mediated uptake of exogenous RNA transfers cellular immunity to a synthetic HIV-1 peptide in human lymphocytes.

Changes in intracellular calcium concentration deeply affect the differentiation of non-excitable cells, including elements of the vertebrate skeleton.

Osteoarthritis gradually destroys articular cartilage; its rising prevalence tracks with increasing life expectancy and obesity.

Undifferentiated mesenchymal stem cells are a key source for cell-based cartilage regeneration through chondrogenic differentiation.

Mitochondria buffer intracellular calcium transients; the protein Miro helps regulate mitochondrial calcium homeostasis in cell survival.

Tumour progression depends on the interaction between tumour cells and the surrounding microenvironment, in which mesenchymal stem cells are active participants.

In a somatic mouse breast cancer model, mesenchymal stem cells home to the tumour but do not accelerate tumorigenesis.

Mesenchymal stem cells recruited to the gut promote the formation of colorectal tumours in a mouse model.

Insufficient intracellular calcium causes mitochondrial dysfunction and inactivates mesenchymal stem cells; an abstract introducing SAC, the research name for AIC, for aging-related degenerative disease.

Effects of repeated ionomycin-induced calcium influx on the in vitro development of bovine somatic cell nuclear transfer embryos.

A review of how calcium signalling governs stem cell self-renewal, differentiation, and fate across tissue types.
Notice: the research articles above are shared here for your convenience and information only. The same articles can be found through PubMed or NIH. ACRI is not directly involved in this research and is not making any claims.
In collaboration with Moffitt Cancer Center, the UAMS Rockefeller Cancer Institute, and the Calcium & Bone Health Institute. Industry partners, institutional research groups, and grant-ready consortia are invited to reach out.
Propose a collaborationThese statements have not been evaluated by the Food and Drug Administration. Antiorbital Ionic Calcium is not intended to diagnose, treat, cure, or prevent any disease. Research is ongoing and outcomes vary.